Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity |
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| Authors: | Stead P Hiscox S Robinson P S Pike N B Sidebottom P J Roberts A D Taylor N L Wright A E Pomponi S A Langley D |
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| Affiliation: | Bioprocessing Unit, Glaxo-Wellcome Medicines Research Centre, Stevenage, Herts, UK. ps29705@glaxowellcome.co.uk |
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| Abstract: | ![]()
We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro. |
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