Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv |
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| Authors: | Louh Gabin Nselapi Lannang Alain Meli Mbazoa Celine Djama Tangmouo Jean Gustave Komguem Justin Castilho Paula Ngninzeko Fernande Ngounou Qamar Naz Lontsi David Choudhary Muhammad Iqbal Sondengam Beiban Luc |
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| Institution: | Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. |
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| Abstract: | Three xanthones, polyanxanthone A (1), B (2) and C (3) have been isolated from the methanol extract of the wood trunk of Garcinia polyantha, along with five known xanthones: 1,3,5-trihydroxyxanthone (4); 1,5-dihydroxyxanthone (5); 1,3,6,7-tetrahydroxyxanthone (6); 1,6-dihydroxy-5-methoxyxanthone (7) and 1,3,5,6-tetrahydroxyxanthone (8). Their structures were determined by means of 1D- and 2D-NMR techniques. Some of the above compounds were screened for their anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. |
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| Keywords: | Garcinia polyantha Polyanxanthone A Polyanxanthone B Polyanxanthone C Prenyloxyxanthones Anticholinesterase |
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