Osteoblastic cells: differentiation and trans-differentiation |
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| Authors: | Kassem Moustapha Abdallah Basem M Saeed Hamid |
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| Affiliation: | Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital & Medical Biotechnology Centre, University of Southern Denmark, Kloevervaenget 6, 4th floor, DK-5000 Odense C, Denmark |
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| Abstract: | The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation. |
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| Keywords: | Osteoblast hMSC Stem cells Differentiation Trans-differentiation |
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