Yeast and drug discovery |
| |
Authors: | Hughes Timothy R |
| |
Institution: | (1) Banting and Best Department of Medical Research, University of Toronto, 112 College St., Toronto, ON M5G 1L6, Canada, |
| |
Abstract: | Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast
Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed
analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it
is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast
have been in widespread use less than a decade – a period shorter than the typical cycle from target identification to marketing
approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds
have yet to be realized.
Electronic Publication |
| |
Keywords: | Yeast Drug discovery Pharmaceutical industry High-throughput screening |
本文献已被 PubMed SpringerLink 等数据库收录! |
|