| 极低频磁场对人肝癌细胞生长、代谢及细胞周期的影响 |
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| 引用本文： | 董良,黄玲珍,陈彦田,耿涛,肖登明,齐瀚实.极低频磁场对人肝癌细胞生长、代谢及细胞周期的影响[J].现代生物医学进展,2005,5(3):1-6. |
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| 作者姓名： | 董良 黄玲珍 陈彦田 耿涛 肖登明 齐瀚实 |
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| 作者单位： | 1. 上海交通大学细胞工程中心,200030
2. 上海交通大学电子信息与电气工程学院,200030 |
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| 基金项目： | 国家自然科学基金资助项目(50477007)~~ |
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| 摘 要： | 目的研究一定参数的极低频磁场对人肝癌细胞(SK-HEP-1)在诸多方面的影响。方法在整个SK-HEP-1细胞的培养周期中用50Hz,20mT的极低频磁场对其进行作用,并检测作用后细胞的增殖活性、生长动力学、代谢以及细胞周期的变化。结果50Hz,20mT的极低频磁场对SK-HEP-1细胞的生长与代谢有抑制作用,并能阻碍其有丝分裂的进行。结论50Hz,20mT的极低频磁场为治疗人类恶性肿瘤提供了一种可能的手段。
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| 关 键 词： | 极低频磁场 人肝癌细胞 增殖活性 生长动力学 代谢 细胞周期 |
Effects of extremely low frequency magnetic field on growth kinetics, metabolism and cell cycle of human liver cancer cells |
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| DONG Liang,HUANG Ling-zhen,CHEN Yan-tian,GENG Tao,XIAO Deng-ming,QI Han-shi.Effects of extremely low frequency magnetic field on growth kinetics, metabolism and cell cycle of human liver cancer cells[J].Progress in Modern Biomedicine,2005,5(3):1-6. |
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| Authors: | DONG Liang HUANG Ling-zhen CHEN Yan-tian GENG Tao XIAO Deng-ming QI Han-shi |
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| Institution: | DONG Liang,HUANG Ling-zhen,CHEN Yan-tian,et al DONG Liang,CHEN Yan-tian,GENG Tao,QI Han-shi,Cell Culture & Bioprocess Engineering Center,Shanghai Jiao Tong University,Shanghai 200030,China HUANG Ling-zhen,XIAO Deng-ming,School of Electric Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China Correspondence to: QI Han-shi,Room 304,Institute of Biotechnology,Shanghai Jiao Tong University,No. 2678 Qixin Road,Shanghai 201101,China |
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| Abstract: | Objective: To study the effects of extremely low frequency (ELF) magnetic field with fixed parameters on human liver cancer cells (SK-HEP-1) at different aspects. Methods: SK-HEP-1 cells were exposed to 50Hz, 20mT magnetic field during the whole culture process, and then proliferation activity, growth kinetics, metabolic profile and cell cycle were analyzed. Results: 50Hz, 20mT magnetic field inhibits the growth and metabolism of SK-HEP-1 cells, and hampers their mitotic division. Conclusion: 50Hz, 20mT magnetic field could be a potential therapy in the treatment of human malignant tumors. |
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| Keywords: | ELF magnetic field human liver cancer cell proliferation activity growth kinetics metabolism cell cycle |
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