三七总皂苷抗肝纤维化作用机制的研究进展

肝纤维化是各种慢性肝病共同的病理基础，是慢性肝病发展到肝硬化、肝癌的必经途径。寻找有效的抗肝纤维化药物是近年研究的热点，其中对三七的研究也取得了很大进展。现综述近几年三七皂苷在保护肝细胞、抑制肝星形细胞活化、促进肝星形细胞凋亡、抑制细胞外基质的合成及促使其降解等方面的作用及可能机制，同时也阐述了三七总皂苷在抗肝纤维化中的重要意义及应用前景。

Research Progress in Anti-hepatic Fibrosis Effects of Saponins from Panax Notoginseng

Hepatic fibrosis is an essential pathological process involved in various chronic hepatic diseases that may deteriorate into hepatic cirrhosis and hepatic cancer. Thus, it has become hot topics to seek bioactive components against hepatic fibrosis. Many researches found that saponins from Panax notoginseng have the potential to be a bioaetive agent against hepatic fibrosis. This review summarizes the research findings that saponins from Panax notoginseng showed a protection of hepatic cells from the fibrosis by inhibition of hepatic stellate cells and synthesis of extracellularmatrix, promoting apop tosis of hepatic stellate cells and degradation of extracellularmatrix. The prospects of saponins from Panax notoginseng in management of hepatic fibrosis are also elaborated.