The interactions of cobalt(II) with mitochondria from rat liver |
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| Authors: | Marcantonio Bragadin Antonio Toninello Mario Mancon Sabrina Manente |
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| Affiliation: | (1) Dipartimento di Scienze Ambientali, Università Cà Foscari, Venezia DD 2137, 30123 Venice, Italy;(2) Dipartimento di Chimica Biologica, Università di Padova e Centro Studio delle Biomembrane, C.N.R. Padova, Viale G. Colombo 3, 35121 Padua, Italy |
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| Abstract: | The interactions of Co2+ with mitochondria have been investigated. The results indicate that Co2+ inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP. |
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| Keywords: | Cobalt Mitochondria Energy synthesis |
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