The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality |
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| Authors: | Cinta Llibre Elisabet Zamora Àngel Caballero Josep Lupón Alba Ros Nuria Benito |
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| Affiliation: | 1. Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol, Badalona, Spain,;2. Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol, Badalona, Spain,;3. Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain, and |
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| Abstract: | Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n?=?182) and discharge (n?=?85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46–4], p?=?0.001) and ΔST2 (HR 2.32 [95% CI 1.21–4.57], p?=?0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information. |
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| Keywords: | Acute heart failure biomarkers outcomes ST2 prognosis |
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