|
|||||
|
|
Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock |
|
| Authors: | Justin B Belsky Daniel C Morris Ralph Bouchebl Michael R Filbin Kevin R Bobbitt Anja K Jaehne |
| Institution: | 1. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA, jbelsky@partners.org;3. Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA,;4. Department of Emergency Medicine, American University of Beirut, Beirut, Lebanon,;5. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA,;6. Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA, and;7. Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA,;8. Department of Quality, Northstar Health System, Iron River, MI, USA |
| Abstract: | Objective: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls.Results: F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay’s lowest detection range (78?ng/ml).Conclusions: F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock. |
| Keywords: | Actin actin binding protein coronary artery bypass graft F-actin G-actin septic shock thymosin beta 4 |