Identification of genetic variants in TNF receptor 2 which are associated with the development of cervical carcinoma |
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| Authors: | Pallavi Singhal Upma Sharma Showket Hussain Alo Nag |
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| Affiliation: | 1. Division of Molecular Genetics and Biochemistry, ICPO, ICMR, Noida, India;2. Department of Biochemistry, University of Delhi South Campus (UDSC), New Delhi, India;3. Department of Biochemistry, University of Delhi South Campus (UDSC), New Delhi, India |
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| Abstract: | Cervical cancer is one of the most common malignancies among women in India. Beside HPV, other factors present in host also put their role in the progression of cervical tumerogenesis. In present study, we screened 300 subjects to identify variations in TNFR2 gene by PCR-dHPLC method followed by direct sequencing. We identified six known and four novel variations in six different exons of TNFR2 gene. Out of these identified variations, five known variations were found to be significantly associated with the risk of cervical cancer (p?TNFR2 gene along with HPV infection and tobacco consumption may lead to the development of cervical cancer. |
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| Keywords: | Cervical cancer dHPLC HPV polymorphism TNFR2 |
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