SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation |
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Authors: | James Erle Wolfe Shin’ichi Ishiwata Filip Braet Renee Whan Yingying Su Sean Lal Cristobal G dos Remedios |
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Institution: | 1.Muscle Research Unit, Department of Anatomy & Histology, Bosch Institute, Sydney Medical School,The University of Sydney,Sydney,Australia;2.Department of Physics, Faculty of Science and Engineering,Waseda University,Shinjuku-ku, Tokyo,Japan;3.Australian Centre for Microscopy and Microanalysis,The University of Sydney,Sydney,Australia |
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Abstract: | Striated muscle is well known to exist in either of two states—contraction or relaxation—under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under conditions of partial activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is characterised by auto-oscillation between rapid-lengthening and slow-shortening phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the result of fluctuating Ca2+ levels, but is rather an intrinsic and fundamental phenomenon of the actomyosin motor. Summarised in this review are the experimental data on SPOC and its fundamental mechanism. SPOC presents a novel technique for studying independent communication and coordination between sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may represent a new way of demonstrating functional defects of sarcomeres in human heart failure. |
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Keywords: | SPOC Auto-oscillation Cardiac muscle Skeletal muscle Sarcomere |
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