A High-Resolution Interval Map of the q21 Region of the Human X Chromosome |
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| Authors: | Christophe Philippe Ccile Arnould Frdrique Sloan Hans van Bokhoven Saskia D van der Velde-Visser Michle Chery H Hilger Ropers Simone Gilgenkrantz Anthony P Monaco Frans P M Cremers |
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| Institution: | Christophe Philippe, Cécile Arnould, Frédérique Sloan, Hans van Bokhoven, Saskia D. van der Velde-Visser, Michèle Chery, H. Hilger Ropers, Simone Gilgenkrantz, Anthony P. Monaco,Frans P. M. Cremers |
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| Abstract: | In a previous study, we have developed a panel of chromosomal rearrangements for the physical mapping of the q13-q21 region of the human X chromosome (Philippe et al., Genomics 17: 147-152, 1993). Here, we report the physical localization of 36 additional polymorphic markers by polymerase chain reaction analysis. The high density of chromosomal breakpoints in Xq21 allows us to map 58 DNA loci in 22 intervals. As a result, this segment of the X chromosome is saturated with approximately three sequence tagged sites per megabase of DNA, which will facilitate the construction of a YAC contig of this region. |
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