Glycosylation reaction of unprotected sugars with hydroxyalkylthymine |
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| Authors: | Zerrouki Rachida Billard Luc Granet Robert Krausz Pierre |
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| Institution: | Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France. |
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| Abstract: | Under mild conditions (Lewis acid/solvent/room temperature), the reaction of unprotected glucose, deoxyribose or xylose with hydroxylalkylthymine gives selectively nucleoside analogs with a spacer arm between sugar and base moiety. Experimental conditions (Lewis acid, solvent) for this new strategy leading to nucleoside analogs synthesis are discussed. |
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