Analysis of <Emphasis Type="Italic">Canis</Emphasis> mitochondrial DNA demonstrates high concordance between the control region and ATPase genes |
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| Authors: | Linda Y Rutledge Brent R Patterson Bradley N White |
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| Institution: | (1) Environmental and Life Sciences Graduate Program, DNA Building, Trent University, 2140 East Bank Drive, K9J 7B8 Peterborough, ON, Canada;(2) Ontario Ministry of Natural Resources, Wildlife Research Development Section, Trent University, DNA Building, 2140 East Bank Drive, K9J 7B8 Peterborough, ON, Canada;(3) Biology Department, Natural Resources DNA Profiling & Forensic Centre, Trent University, DNA Building, 2140 East Bank Drive, K9J 7B8 Peterborough, ON, Canada |
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| Abstract: | Background Phylogenetic studies of wild Canis species have relied heavily on the mitochondrial DNA control region (mtDNA CR) to infer species relationships and evolutionary
lineages. Previous analyses of the CR provided evidence for a North American evolved eastern wolf (C. lycaon), that is more closely related to red wolves (C. rufus) and coyotes (C. latrans) than grey wolves (C. lupus). Eastern wolf origins, however, continue to be questioned. Therefore, we analyzed mtDNA from 89 wolves and coyotes across
North America and Eurasia at 347 base pairs (bp) of the CR and 1067 bp that included the ATPase6 and ATPase8 genes. Phylogenies
and divergence estimates were used to clarify the evolutionary history of eastern wolves, and regional comparisons of nonsynonomous
to synonomous substitutions (dN/dS) at the ATPase6 and ATPase8 genes were used to elucidate the potential role of selection in shaping mtDNA geographic distribution. |
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