Molecular tweezers for enantiodiscrimination in NMR: Di‐(R,R)‐1‐[10‐(1‐hydroxy‐2,2,2‐trifluoroethyl)‐9‐anthryl]‐2,2,2‐trifluoroethyl benzenedicarboxylates |
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| Authors: | Sergio Gil Martina Palomino‐Schätzlein Kepa Koldo Burusco Carlos Jaime Albert Virgili |
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| Institution: | Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain |
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| Abstract: | A series of new chiral molecular tweezers, di‐(R,R)‐1‐10‐(1‐hydroxy‐2,2,2‐trifluoroethyl)‐9‐anthryl]‐2,2,2‐trifluoroethyl phthalate (2), isophthalate (3) and terephthalate (4), were synthesized and their structure studied by NMR and molecular mechanics. Their effectiveness as chiral solvating agents for the determination of the enantiomeric purity of chiral compounds using NMR was demonstrated. Chirality 2010. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | chiral solvating agents enantiodiscrimination NMR enantiomeric excess molecular tweezers |
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