Effect of GRF and somatostatin on 7B2 secretion by rat GH1 cells |
| |
| Authors: | H Iguchi S Natori H Nawata |
| |
| Institution: | Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan. |
| |
| Abstract: | A novel pituitary protein "7B2" was secreted by GH1 cells. The secretion of 7B2 was increased in the presence of human GRF in a dose-responsive manner. In contrast, a somatostatin analog, SMS 201-995, revealed the inhibitory effects on the basal- and GRF-induced secretion of 7B2 at the concentration of 10(-7) M. These findings suggest that 7B2 is a secretory protein of rat GH1 cells under certain conditions. |
| |
| Keywords: | |
|
|
