AmylPepPred: Amyloidogenic Peptide Prediction tool |
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Authors: | Smitha Sunil Kumaran Nair NV Subba Reddy KS Hareesha |
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Affiliation: | 1Department of Computer Science and Engineering, Manipal Institute of Technology, Manipal University, Karnataka, India;2Mody Institute of Technology and Science University, Rajasthan, India |
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Abstract: | We present an efficient computational architecture designed using supervised machine learning model to predict amyloid fibrilforming protein segments, named AmylPepPred. The proposed prediction model is based on bio-physio-chemical properties ofprimary sequences and auto-correlation function of their amino acid indices. AmylPepPred provides a user friendly web interfacefor the researchers to easily observe the fibril forming and non-fibril forming hexmers in a given protein sequence. We expect thatthis stratagem will be highly encouraging in discovering fibril forming regions in proteins thereby benefit in finding therapeuticagents that specifically aim these sequences for the inhibition and cure of amyloid illnesses.AvailabilityAmylPepPred is available freely for academic use at www.zoommicro.in/amylpeppred |
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Keywords: | Amyloid fibrils Bio-physio-chemical properties Auto-correlation function Support Vector Machine AmylPepPred |
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