(1) National Center for Biotechnology Information, National Institutes of Health, 20894 Bethesda, MD, USA
Abstract:
Background
In general, the length of a protein sequence is determined by its function and the wide variance in the lengths of an organism's proteins reflects the diversity of specific functional roles for these proteins. However, additional evolutionary forces that affect the length of a protein may be revealed by studying the length distributions of proteins evolving under weaker functional constraints.