Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever |
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| Authors: | Geris Regina Rodrigues-Fo Edson Garcia da Silva Heloísa Helena Garcia da Silva Ionizete |
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| Affiliation: | 1. Instituto de Química, Universidade Federal da Bahia, Rua Bar?o de Geremoabo s/n, Ondina, Salvador – BA, 41950‐350, Brasil (phone: +55‐1‐3263‐6817;2. fax: 55‐71‐3237‐4117);3. Departamento de Química, Universidade Federal de S?o Carlos, CP 676, 13.565‐905, SP, Brasil;4. Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, CP 131, 74001‐970, GO, Brasil |
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| Abstract: | The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC(50) and LC(90)) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC(50) value of 2.9 ppm, making it an attractive natural insecticide. |
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| Keywords: | Larvicidal activity Aedes aegypti Mosquito Dengue Yellow Fever Meroterpenoids Insecticides Dehydroaustin Metabolites |
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