Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae |
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| Authors: | Yanping Zou Yong Li Moon-Moo Kim Sang-Hoon Lee Se-Kwon Kim |
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| Institution: | (1) Marine Bioprocess Research Center, Pukyong National University, Busan, 608-737, Korea;(2) Resource Institute, Academy of Sciences of Traditional Chinese Medicine of Jilin Province, Changchun, 130021, China;(3) Department of Chemistry, Dong-Eui University, Busan, 614-714, Korea;(4) Department of Chemistry, Pukyong National University, Busan, 608-737, Korea |
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| Abstract: | A new glyceroglycolipid, ishigoside (1, 2-di-O-palmitoyl-3-O-(6-deoxy-6-amino)-α-D-glucopyranosyl-glycerol, 1), along with two known compounds were isolated from the brown alga Ishige okamurae. The structure of the new compound was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, MS techniques
and chemical methods. Moreover, direct free radical scavenging activities of ishigoside were investigated by electron spin
resonance spectrometry (ESR) technique. The results suggested that ishigoside was a potential free-radical scavenger against
DPPH, hydroxyl, alkyl, and superoxide radicals with the EC50 of 31.2, 16.7, 22.7, and 26.8 μM, respectively. |
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| Keywords: | Ishige okamurae ishigoside glyceroglycolipid free radical scavenging activity ESR |
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