Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase |
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Authors: | Amjesh Revikumar Achuthsankar Sukumaran Nair Sugunan Vetha Sundaram |
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Institution: | 1Centre for Bioinformatics, University of Kerala, Trivandrum 695581, India;2Department of Zoology, His Highness The Maharaja''s University College, Trivandrum, 695034, Kerala, India |
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Abstract: | Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected
individuals at a risk of developing significant morbidity and mortality. There is no effective treatment or prevention till date for
HCV infection. We describe the computed binding of 10 compounds to the allosteric binding site of RNA dependent RNA
polymerase enzyme. These compounds were identified from the ZINC database through virtual screening followed by ADMET
evaluation. |
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