The Role of Circadian Clocks in Metabolic Disease |
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| Authors: | Min-Dian Li Chao-Min Li Zhong Wang |
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| Affiliation: | aDepartment of Cellular and Molecular Physiology, Section of Comparative Medicine, and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale School of Medicine, New Haven, Connecticut;bChengdu Univerisity of Traditional Chinese Medicine, Chengdu, Sichuan, China;cChengdu Geriatric Hospital, Chengdu, Sichuan, China |
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| Abstract: | The circadian clock is a highly conserved timing system, resonating physiologicalprocesses to 24-hour environmental cycles. Circadian misalignment is emerging asa risk factor of metabolic disease. The molecular clock resides in all metabolictissues, the dysfunction of which is associated with perturbed energymetabolism. In this article, we will review current knowledge about molecularmechanisms of the circadian clock and the role of clocks in the physiology andpathophysiology of metabolic tissues. |
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| Keywords: | circadian clocks metabolism metabolic disease |
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