Asymmetric synthesis of all stereoisomers of 6-methylpipecolic acids |
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Authors: | Takahata H Shimizu M |
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Institution: | (1) Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai, Japan, JP;(2) Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Toyama, Japan, JP |
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Abstract: | Summary. Asymmetric synthesis of all four stereoisomers of 6-methylpipecolic acids with high enantiomeric purity via iterative AD
reaction, starting from 1,6-heptadiene, has been described.
Received March 25, 2002 Accepted June 15, 2002 Published online January 30, 2003
Authors' address: Hiroki Takahata, Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan, E-mail: takahata@tohoku-pharm.ac.jp
RID="*"
ID="*" The stereo-configurations of 8 and 9 in Fig. 3 and 12 in Fig. 4 show only major isomers.
RID="**"
ID="**" The absolute configurations of 11 and 14 |
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Keywords: | : Asymmetric synthesis 6-Methypipecolic acid Asymmetric dihydroxylation Enantiomeric enhancement |
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