| 实验性自身免疫性心肌炎动物模型的建立与评价 |
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| 引用本文： | 李萌,吕仕超,吴美芳,张军平.实验性自身免疫性心肌炎动物模型的建立与评价[J].中国实验动物学杂志,2013(2):69-72. |
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| 作者姓名： | 李萌 吕仕超 吴美芳 张军平 |
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| 作者单位： | [1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193 |
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| 基金项目： | 高等学校博士学科点专项科研基金（20111210110003） |
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| 摘 要： | 实验性自身免疫性心肌炎动物模型（ experimental autoimmune myocarditis, EAM）作为自身免疫性心肌炎机制、诊断、药物治疗等实验研究的重要载体，在心肌炎科学研究中发挥着重要的作用。本文针对EAM模型的建立及评价予以综述，分别对心肌自身抗原、心肌自身抗原表位、活化自身免疫细胞、干酪乳杆菌细胞壁成分等介质诱导的EAM模型进行整理总结，分析比较各造模方法的特点并阐述EAM模型的评价方法，为建立客观的EAM模型提供有效依据。
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| 关 键 词： | 心肌炎 自身免疫性 模型，动物 |
A review on the establishment and evaluation of animal models of experimental autoimmune myocarditis |
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| LI Meng,LV Shi-chao,WU Mei-fang,ZHANG Jun-ping.A review on the establishment and evaluation of animal models of experimental autoimmune myocarditis[J].Chinese Journal of Laboratory Animal Science,2013(2):69-72. |
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| Authors: | LI Meng LV Shi-chao WU Mei-fang ZHANG Jun-ping |
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| Institution: | 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 2. the First Affiliated Hospital of Tianjin University of Traditional Chinese Medieine, Tianjin 300193, China) |
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| Abstract: | Animal models of experimental autoimmune myocarditis （EAM） have played very important role in the research on the mechanism, diagnosis and treatment of myocarditis. This article summarizes the establishment and evaluation of EAM models induced by myocardial autoantigen, myocardial autoantigen epitope, activated autoimmune cell and lactobacillus cell wall extract, which clarifies the characteristics and evaluation methods of various models, and provides an effective basis for objective establishment of EAM models. |
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| Keywords: | Autoimmune myocarditis Models animal |
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