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Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes |
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| Authors: | Andrew R Williams Sara E Zakutansky Kazutoyo Miura Matthew DJ Dicks Thomas S Churcher Kerry E Jewell Aisling M Vaughan Alison V Turner Melissa C Kapulu Kristin Michel Carole A Long Robert E Sinden Adrian VS Hill Simon J Draper Sumi Biswas |
| Institution: | 1. The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK;2. Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD 20852, USA;3. Department of Infectious Disease Epidemiology, Imperial College London, London, UK;4. Kansas State University, Division of Biology, Manhattan, KS 66506, USA;5. Division of Cell and Molecular Biology, Imperial College London, London, UK |
| Abstract: | The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines. |
| Keywords: | Malaria Vaccine Mosquito Antibodies Serpins |
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