Commensal bacteria‐dependent select expression of CXCL2 contributes to periodontal tissue homeostasis |
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| Authors: | Ahmed Hashim Toshiharu Abe Lijian Jin Yucheng Chang Zhi Chao Jin Jian Xun Sun George Hajishengallis Mike A Curtis Richard P Darveau |
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| Institution: | 1. Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, , London, E1 2AT UK;2. Department of Microbiology, University of Pennsylvania School of Dental Medicine, , Philadelphia, PA, 19104 USA;3. Faculty of Dentistry, Periodontology, The University of Hong Kong, , Hong Kong, China;4. Department of Periodontics, University of Washington School of Dentistry, , Seattle, WA, 98195 USA;5. Department of Health Statistics, The Second Military Medical University, , Shanghai, 200433 China;6. State key laboratory of oral diseases, West China School of Stomatology, Sichuan University, , Chengdu, 610041 China;7. Department of Microbiology, University of Washington, , Seattle, WA, 98195 USA |
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| Abstract: | The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy intestinal tissue structure and function, their contribution to oral health is poorly understood. A crucial component of periodontal health is the recruitment of neutrophils to periodontal tissue. To elucidate this process, gingival tissues of specific‐pathogen‐free and germ‐free wild‐type mice and CXCR2KO and MyD88KO mice were examined for quantitative analysis of neutrophils and CXCR2 chemoattractants (CXCL1, CXCL2). We show that the recruitment ofneutrophils to the gingival tissue does not require commensal bacterial colonization but is entirely dependent on CXCR2 expression. Strikingly, however, commensal bacteria selectively upregulate the expression of CXCL2, but not CXCL1, in a MyD88‐dependent way that correlates with increased neutrophil recruitment as compared with germ‐free conditions. This is the first evidence that the selective use of chemokine receptor ligands contributes to neutrophil homing to healthy periodontal tissue. |
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