Protective Effects of Erdosteine and Vitamins C and E Combination on Ischemia–Reperfusion-Induced Lung Oxidative Stress and Plasma Copper and Zinc Levels in a Rat Hind Limb Model |
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Authors: | Mehmet S?rmal? Efkan Uz Rana S?rmal? Aynur K?lba? H Ramazan Y?lmaz ?rfan Altunta? Mustafa Naz?ro?lu Nam?k Deliba? Hüseyin Vural |
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Institution: | Department of Thoracic Surgery, Süleyman Demirel University Medical School, Isparta, Turkey. mehmetsirmali@yahoo.com |
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Abstract: | The aim of this study was to investigate the protective effects of erdosteine and vitamins C and E (VCE) on the lungs after
performing hind limb ischemia–reperfusion (I/R) by assessing oxidative stress, plasma copper (Cu), and zinc (Zn) analysis.
The animals were divided randomly into four groups as nine rats each as follows: control, I/R, I/R plus erdosteine, and I/R
plus VCE combination. I/R period for 60 min was performed on the both hind limbs of all the rats in the groups of I/R, erdosteine
with I/R, VCE with I/R allowing 120 min of reperfusion. The animals received orally erdosteine one time in a day and 3 days
before I/R in the erdosteine group. In the VCE group, the animals VCE combination received one time in a day and 3 days before
I/R, although placebo was given to control and I/R group animals. Lung lipid peroxidation (malondialdehyde MDA]) level, superoxide
dismutase (SOD), and catalase activities were increased, although lung glutathione (GSH) and plasma Zn levels decreased in
I/R group in lung tissue compared with the control group. Serum MDA level, creatine kinase, and lactate dehydrogenase activities
were increased in I/R group compared with the control. Lung MDA and plasma Zn levels and lung SOD activity were decreased
by erdosteine administration, whereas lung GSH levels after I/R increased. The plasma Zn levels and lung SOD activity were
decreased by VCE administration, although the plasma Cu and lung GSH levels increased after I/R. In conclusion, erdosteine
has an antioxidant role on the values in the rat model, and it has more protective affect than in VCE in attenuating I/R-induced
lung injury in rats. |
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Keywords: | Erdosteine Antioxidant vitamins Ischemia– reperfusion Lung Zinc |
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