|
|||||
|
|
Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements |
|
| Authors: | Brashear Karen M Hunt Cecilia A Kucer Brian T Duggan Mark E Hartman George D Rodan Gideon A Rodan Sevgi B Leu Chi-Tai Prueksaritanont Thomayant Fernandez-Metzler Carmen Barrish Andrea Homnick Carl F Hutchinson John H Coleman Paul J |
| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. karen_brashear@merck.com |
| Abstract: | A series of novel, highly potent alpha(v)beta(3) receptor antagonists with favorable pharmacokinetic profiles has been identified. In this series of antagonists, 2-aryl beta-amino acids function as potent aspartic acid replacements. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |