Energy metabolism in glutamatergic neurons,GABAergic neurons and astrocytes in primary cultures |
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Authors: | Leif Hertz Jørgen Drejer Arne Schousboe |
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Institution: | (1) Dept. of Pharmacology, Univ. of Saskatchewan, S7N 0W0 Saskatoon, Sask., Canada;(2) A/S Ferrosan, Research Division, DK-2860 Soeborg, Denmark;(3) Dept. of Biochemistry A, Panum Institute, Univ. of Copenhagen, DK 2200 Copenhagen, Denmark |
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Abstract: | Several aspects of energy metabolism (glucose utilization, lactate production,14CO2 production from labeled glucose, glutamate or pyruvate, oxygen consumption and contents of ATP and phosphocreatine) were measured in cerebellar granule cells (glutamatergic) in primary cultures and compared with corresponding data for cerebral cortical neurons (mainly GABA-ergic) and astrocytes. Cerebellar granule cells and astrocytes were metabolically more active than cerebral cortical neurons. Glutamate which is utilized as a major metabolic fuel as astrocytes and, to a lesser extent, in cerebral cortical neurons, was virtually not oxidized in cerebellar granule cells.Special Issue dedicated to Prof. Holger Hydén. |
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Keywords: | Glucose pyruvate glutamate ATP metabolism neurons astrocytes |
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