Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression |
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| Authors: | A Kimura A Isra?l O Le Bail P Kourilsky |
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| Affiliation: | 1. Department of Prosthodontics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China;3. Department of Infectious Diseases, Armed Forces Medical Research Institute, 90bun, Jaunro, Yuseong-gu, Daejeon 305-878;4. Department of Immunology, Laboratory of Dendritic Cell Differentiation and Regulation, Konkuk University School of Medicine, Chungju 380-701, South Korea;1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA;2. Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA;3. Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA;4. Department of Hematology and Oncology, Indiana University, Indianapolis, IN;5. Pediatric Hematology and Oncology, St. Jude Children''s Research Hospital, Memphis, TN;6. Immunology and Molecular Pathogenesis Graduate Program, Emory University School of Medicine, Atlanta, GA;7. Aflac Cancer and Blood Disorders Center, Children''s Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA;1. Biomaterials Group, CSIR – Indian Institute of Chemical Technology, Hyderabad, Telangana, India;2. Academy of Scientific and Innovative Research (AcSIR), Chennai, Tamil Nadu, India;1. Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas |
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| Abstract: | Sequencing and deletion analyses of the H-2Kb promoter have suggested that several regions may be important for expression and regulation of this gene. Two of these regions are conserved inside the promoter of several genes coding for classical transplantation antigens, but not in the promoter of class I genes located in the Qa region. They display enhancer-like activity in cells that express H-2 genes, but show some tissue specificity in that they function very poorly in undifferentiated embryonal carcinoma cells in which H-2 genes are not expressed. They also have been shown not to be the target of the adenovirus-12 induced repression of class I gene expression recently demonstrated by Schrier et al. The promoter of the beta 2-microglobulin gene also contains a sequence with enhancer-like activity, but shares no homology with the H-2Kb promoter region. |
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