Loss and recovery of transplantability of L-P59 cells |
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| Authors: | Mislav Jurin |
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| Institution: | (1) Section of Experimental Radiotherapy, The University of Texas at Houston, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, 77025 Texas, Houston;(2) Present address: Department of Biology, Institute Rudjer Bošković, 41001 Zagreb, Croatia, Yugoslavia |
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| Abstract: | Summary After cultivation in vitro for 3 years, L-P59 cells failed to produce tumors in C3Hf/Bu mice. Meanwhile, the cells retained
their antigenic abilities, i.e. they induced resistance in the recipient to subsequent challenge with tumorigenic L-P59 cell
line. After 2 weeks of cultivation in agar, those nontumorigenic cells became again able to transplant the tumor in C3Hf/Bu
recipients.
This work was supported in part by the United States Public Health Service Grants CA 05047 and CA 6294. |
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