Human Plasmacytoid Dendritic Cells Sense Lymphocytic Choriomeningitis Virus-Infected Cells In Vitro |
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| Authors: | S F Wieland K Takahashi B Boyd C Whitten-Bauer N Ngo J-C de la Torre F V Chisari |
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| Institution: | aDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA;bDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan |
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| Abstract: | We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/β) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV). |
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