Efficiency of serum copper/zinc ratio for differential diagnosis of patients with and without lung cancer |
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| Authors: | Tsunehiro Oyama Koji Matsuno Toshihiro Kawamoto Tetsuya Mitsudomi Takayuki Shirakusa Yasushi Kodama |
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| Institution: | (1) Department of Environmental Health, University of Occupational and Environmental Health, 807 Kitakyushu, Japan;(2) Department of Surgery II, University of Occupational and Environmental Health, 807 Kitakyushu, Japan;(3) Present address: Department of Surgery II, Fukuoka University, School of Medicine, Japan |
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| Abstract: | We examined serum copper (Cu), serum zinc (Zn), and the serum copper/zinc ratio (Cu/Zn) in 162 patients. All of them were
seen to have an abnormal shadow in the chest X-ray films, that is, 109 patients with lung cancer (LC) and 53 patients with
no lung cancer (NLC). The mean Cu and Cu/Zn in LC patients were significantly higher than those in NLC patients (p<0.05). In LC patients, Cu and Cu/Zn were higher and Zn was lower in advanced tumors than early ones. There was a significantly
clear relation between Cu or Cu/Zn and the tumor (T) stages. When the relative risk (RR) of LC was estimated, it was seen
that the higher Cu and Cu/Zn became, the higher RR became. Furthermore, we showed the sensitivity of the receiver operator
characteristic of the test (ROC) curve for Cu, Cu/Zn, and carcinoembryonic antigen (CEA) to diagnose LC, as explained in a
paragraph of methods.The determinations of Cu, Zn, and Cu/Zn are simple and inexpensive. They also appear to have a great diagnostic value in determining the local invasion of LC and as a screening test in the
high-risk patients for LC. |
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| Keywords: | Serum copper serum zinc serum copper/zinc ratio carcinoembryonic antigen lung cancer |
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