MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN |
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| Authors: | Ting-Song Yang Xiao-Hu Yang Xi Chen Xu-Dong Wang Jie Hua Dong-Lei Zhou Bo Zhou Zhen-Shun Song |
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| Institution: | Department of General Surgery, Tenth Peoples’ Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China |
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| Abstract: | It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR-106b is associated with poor prognosis of patients, and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR-106b might be a novel candidate target for the treatment of gastric cancer. |
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| Keywords: | CAFs cancer associated fibroblasts NFs normal fibroblasts miRNA microRNA PTEN protein tyrosine phosphatase and tensin homologue α-SMA α-smooth muscle actin FSP1 fibroblast specific protein 1 FAP fibroblast activation protein TGF-β transforming growth factor-β HGF hepatocyte growth factor PDGF platelet-derived growth factor FGF-7 fibroblast growth factor-7 SDF-1 stromal cell-derived factor-1 |
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