MicroRNA-29a suppresses the growth,migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6 |
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| Authors: | Hye Sook Han Seung-Myoung Son Jieun Yun Yeong Nang Jo Ok-Jun Lee |
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| Institution: | 1. Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea;2. Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, South Korea;3. Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, South Korea |
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| Abstract: | Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR-29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. Therefore, miR-29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma. |
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| Keywords: | CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 DNMT DNA methyltransferase IHC immunohistochemical miRNA microRNA NSCLC non-small cell lung cancer TMA tissue microarray |
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