| 高产降胆固醇活性物质的红曲霉菌种选育研究 |
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| 引用本文： | 魏培莲,周立平,毛建卫. 高产降胆固醇活性物质的红曲霉菌种选育研究[J]. 氨基酸和生物资源, 2002, 24(3): 18-22. DOI: 10.3969/j.issn.1006-8376.2002.03.008 |
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| 作者姓名： | 魏培莲 周立平 毛建卫 |
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| 作者单位： | 浙江科技学院生物与化学工程系,杭州,310012;浙江工业大学生物与环境工程学院,杭州,310014 |
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| 摘 要： | 红曲霉出发菌株经紫外线 (UV)、硫酸二乙酯 (DES)、氯化锂 (LiCl)等诱变剂反复诱变处理 ,获得供试红曲霉菌株 10株。用薄层层析法初筛得到可能产MonacolinK的菌株 4株 ,再经高效液相色谱法对初筛菌株进一步进行检测 ,证实其中 3株具有较强的产MonacolinK能力 ,特别是诱变株M7的含量与出发菌株相比提高了 4 1倍
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| 关 键 词： | 红曲霉 诱变育种 MonacolinK 薄层层析 |
| 文章编号： | 1006-8376-(2002)03-0018-05 |
| 修稿时间： | 2001-11-20 |
Breeding and Screening of Monascus Strains Producing Blood-lipid-lowering Materials |
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| WEI Pei-lian ,ZHOU Li-ping ,MAO Jian-wei. Breeding and Screening of Monascus Strains Producing Blood-lipid-lowering Materials[J]. Amino Acids & Biotic Resources, 2002, 24(3): 18-22. DOI: 10.3969/j.issn.1006-8376.2002.03.008 |
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| Authors: | WEI Pei-lian ZHOU Li-ping MAO Jian-wei |
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| Affiliation: | WEI Pei-lian 1,ZHOU Li-ping 2,MAO Jian-wei 1 |
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| Abstract: | The original strain of Monascus was induced by UV radiation, DES and LiC1 and 10 strains were obtained. 4 strains were found possible to produce Monacolin K by TLC, which were further evaluated by HPLC analysis. 3 strains were proved to produce higher Monacolin K, among them M7 was as high as 41 times of the original strain. |
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| Keywords: | Monascus sp monacolin K mutation breeding TLC |
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