Photoregulation of thrombin aptamer activity using Bhc caging strategy |
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| Authors: | YiMing Li Jing Shi ZhaoFeng Luo Hao Jiang XiaoYun Chen FengLiang Wang Xu Wu QingXiang Guo |
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| Affiliation: | aDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, China;bHefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | Thrombin aptamer was attempted to cage with Bhc (6-bromo-7-hydroxycoumarin-4-ylmethyl) group for controlling its specific affinity to target molecular through photolysis. By multiple-caging strategy, aptamer could be rendered biologically inert and partially restored with subsequently illumination. This provides a convenient method for photoregulating aptamer activity with exact spatiotemporal resolution. |
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| Keywords: | Aptamer Caged compound Light-activated Bhc Activity regulation |
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