Characterization and thermodynamic properties of quadruplex/duplex competition |
| |
| Authors: | Li Wei Wu Peng Ohmichi Tastuo Sugimoto Naoki |
| |
| Affiliation: | First Department of Internal Medicine, Aichi Medical University, Yazako-Karimata, Nagakute, Aichi, Japan. harutaka@amugw.aichi-med-u.ac.jp |
| |
| Abstract: | Extracellular superoxide dismutase (EC-SOD) is synthesized in mesenchymally derived cells and prevents the oxygen radical-induced injury. We studied whether kidney mesangial cells (MCs) produce EC-SOD and how its production is associated with chemokine secretion. Under unstimulated condition, MCs produced EC-SOD, and its production was correlated positively with cyclic adenosine monophosphate (cAMP), but negatively with interleukin (IL)-6 or IL-8 production. By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8. The presence of adenylate cyclase inhibitor 2',3'-dideoxyadenosine lost the prednisolone effect. The stimulation of EC-SOD production might be one of the important effects of prednisolone via cAMP pathway in MCs. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
