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Concerted evolution reveals co-adapted amino acid substitutions in Na+K+-ATPase of frogs that prey on toxic toads |
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| Authors: | Shabnam Mohammadi Lu Yang Arbel Harpak Santiago Herrera-Álvarez María del Pilar Rodríguez-Ordoñez Julie Peng Karen Zhang Jay F Storz Susanne Dobler Andrew J Crawford Peter Andolfatto |
| Institution: | 1. School of Biological Sciences, University of Nebraska, Lincoln, NE, USA;2. Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA;3. Department of Biological Sciences, Columbia University, New York, NY, USA;4. Department of Biological Sciences, Universidad de los Andes, Bogotá 111711, Colombia;5. Lewis-Sigler Institute, Princeton University, Princeton, NJ, USA;6. Molecular Evolutionary Biology, Zoological Institute, Universität Hamburg, Hamburg, Germany |
| Abstract: | |
| Keywords: | sodium potassium ATPase ATP-alpha subunit gene duplication cardiotonic steroids toxin resistance non-allelic gene conversion molecular evolution natural selection epistasis neofunctionalization |
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