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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
Authors:Deepti Lall  Ileana Lorenzini  Thomas A. Mota  Shaughn Bell  Thomas E. Mahan  Jason D. Ulrich  Hayk Davtyan  Jessica E. Rexach  A.K.M. Ghulam Muhammad  Oksana Shelest  Jesse Landeros  Michael Vazquez  Junwon Kim  Layla Ghaffari  Jacqueline Gire O’Rourke  Daniel H. Geschwind  Mathew Blurton-Jones  David M. Holtzman  Robert H. Baloh
Affiliation:1. Center for Neural Science and Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA;2. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA;3. Department of Neurology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA;4. Department of Neurobiology, Barrow Neurological Institute, 350 W. Thomas Road, Phoenix, AZ 85013, USA;5. Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, St. Louis, MO 63110, USA;6. Institute for Memory Impairments and Neurological Disorders, Sue & Bill Gross Stem Cell Research Center, 3200 Gross Hall, 845 Health Sciences Road, University of California, Irvine, Irvine, CA 92697, USA;7. Program in Neurogenetics, Department of Neurology, Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:amyotrophic lateral sclerosis  frontotemporal dementia  Alzheimer’s disease  microglia  neurodegeneration
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