Comparative analysis of the cattle and human genomes: detection of ZOO-FISH and gene mapping-based chromosomal homologies |
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| Authors: | B P Chowdhary L Frönicke I Gustavsson H Scherthan |
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| Institution: | (1) Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, S-750 07 Uppsala, Sweden, SE;(2) Division of Human Biology and Human Genetics, University of Kaiserslautern, Erwin-Schroedingerstr., D-67663 Kaiserslautern, Germany, DE |
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| Abstract: | Comparative chromosome painting with individual human chromosome-specific libraries (CSLs) on cattle metaphase chromosomes
delineated 46 homologous chromosomal segments between the two species. Continuous arrangement of these segments on individual
cattle chromosomes demonstrates a nearly complete coverage of the bovine karyotype and shows physical boundaries of bovine
chromosomal segments homologous to individual human chromosomes. Alignment of the available comparative gene mapping data
with the homologous segments strongly supports the detected gross homologies between the karyotypes of the two species. In
addition to cattle, four human CSLs were hybridized to sheep metaphase chromosomes also, to further verify the known karyotype
homology within the Bovidae. Besides its application to karyotype evolution research, the comparative knowledge provides for
rapid expansion of the much needed Type I locus-based bovine gene map.
Received: 9 September 1995 / Accepted: 4 December 1995 |
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