| 核糖体蛋白参与调控p53诱导活化的分子机制 |
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| 引用本文： | 李小光,宋伦,袁胜涛.核糖体蛋白参与调控p53诱导活化的分子机制[J].生物技术通讯,2013(3):423-426. |
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| 作者姓名： | 李小光 宋伦 袁胜涛 |
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| 作者单位： | [1]中国药科大学新药筛选中心,江苏南京210009 [2]军事医学科学院基础医学研究所,北京100850 |
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| 基金项目： | 国家重点基础研究发展计划（2011CB530008）;国家自然科学基金（31171342,31270797） |
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| 摘 要： | 核转录因子p53是重要的肿瘤抑制因子，具有DNA损伤修复、促细胞凋亡、促细胞分化及增殖抑制等功能，并通过调控细胞周期行进和促进细胞凋亡发挥肿瘤抑制功能。原癌蛋白MDM2为p53的E3泛素化连接酶，MDM2－p53信号轴的功能异常与多种恶性肿瘤的发生发展相关。核糖体蛋白（RP）是蛋白质合成反应的关键调节蛋白，其功能失常与多种疾病相关。近年来的研究发现，RP能通过调节MDM2－p53信号轴在p53相关性肿瘤调控中发挥重要作用。我们根据目前的研究进展，对RP－MDM2－D53信号轴进行简要综述。
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| 关 键 词： | 核糖体蛋白 MDM2 p53 |
Critical Role of Ribosomal Proteins Involving in Regulating p53 Activity |
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| LI Xiao-Guang,SONG Lun,YUAN Sheng-Tao.Critical Role of Ribosomal Proteins Involving in Regulating p53 Activity[J].Letters in Biotechnology,2013(3):423-426. |
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| Authors: | LI Xiao-Guang SONG Lun YUAN Sheng-Tao |
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| Institution: | 1. New Drug Screening Center, China Pharmaceutical University, Nanjing 210009; 2. Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850; China) |
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| Abstract: | As an important tumor suppressor, p53 plays an essential role in maintaining cell homeostasis and preventing tumourigenesis by inducing DNA repair, apoptosis, cell division and growth suppression. Oncoprotein MDM2 functions as one of the E3 ubiquitin ligases of p53 and the abnormality in MDM2-p53 signaling cascade contributes largely to tumor initiation and progression. It＇s recently reported that ribosomal proteins（RP）, the key players in protein synthesis, exerts a role in modulating MDM2-p53 pathway and therefore functions as a novel regulator in p53-related cancers. Here we summarized the recent data regarding the RP-MDM2-p53 pathway. |
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| Keywords: | ribosomal proteins MDM2 p53 |
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