| 人脐带间充质干细胞对CCl4诱导肝纤维化的治疗作用研究 |
| |
| 引用本文： | 陈冬波,王科,王慧娜,宋亚坤,杜丽欣,罗建安,杨志岗,吴东颖,祝春青,邱泽武,刘兵,吕双红. 人脐带间充质干细胞对CCl4诱导肝纤维化的治疗作用研究[J]. 生物技术通讯, 2013, 0(3): 347-350 |
| |
| 作者姓名： | 陈冬波 王科 王慧娜 宋亚坤 杜丽欣 罗建安 杨志岗 吴东颖 祝春青 邱泽武 刘兵 吕双红 |
| |
| 作者单位： | [1]解放军307医院307-青藤转化医学中心,北京100071 [2]解放军307医院消化科,北京100071 [3]北京青藤谷禧干细胞科技研究院有限公司,北京100071 |
| |
| 基金项目： | 国家科技支撑计划（2012BAI38803） |
| |
| 摘 要： | 目的：探讨人脐带间充质干细胞（UC-MSC）治疗肝纤维化的可行性。方法：采用CCL腹腔注射小鼠制备肝纤维化模型，分别于第4、10周给予尾静脉注射移植UC-MSC进行治疗，检测治疗后血清学指标的改变和病理变化，观察UC-MSC对肝纤维化的疗效。结果：4周和10周进行治疗均可改善肝功能，减轻纤维化程度。结论：UC-MSC对CCl4诱导的肝纤维化具有一定的疗效。
|
| 关 键 词： | 肝纤维化 间充质干细胞 CCl4 |
Therapeutic Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of CCl4 Induced Liver Fibrosis |
| |
| Affiliation: | CHEN Dong-Bo, WANG Kela, WANG Hui-Na. SONG Ya-Kun, DU Li-Xin, LUO Jan-An, YANG Zhi-Gang, WU Dong-Ying, ZHU Chun-Qing, QIU Ze-Wu, LIU Bing, LIU Shuang-Hong(1. a. 307-Ivy Translational Medicine Center; b. Department of Gastroenterology; 307 Hospital of PLA, Beijing 100071; 2. Beijing Ivy Stem Cell Corp., Beijing 100071; China) |
| |
| Abstract: | Objective： To evaluate the use of umbilical cord-derived mesenchymal stem cells（UC-MSC） to treat chemically induced liver fibrosis. Methods： Liver fibrosis was replicated in mice via intraperitoneal injection of carbon tetrachloride（CCl4）. After 4 or 10 weeks of injection, UC-MSC were transplanted into liver damaged mice via the tail vein and the treatment was evaluated by assessing serum biochemistry and histopathology. Results： In comparison with mice treated with CCl4 without UC-MSC transplantation, animals in the treatment group had significantly improved serum biochemical results and exhibited a significant reduction in liver fibrosis, as evidenced by masson＇s trichrome staining. Conclusion： Human UC-MSC promoted recovery after liver fibrosis. |
| |
| Keywords: | liver fibrosis mesenchymal stem cells carbon tetraehloride |
| 本文献已被 维普 等数据库收录！ |
|
