| PDZ结构域介导的PIP脂质信号转导 |
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| 引用本文： | 冯巍,张明杰. PDZ结构域介导的PIP脂质信号转导[J]. 生命科学, 2011, 0(11): 1095-1100 |
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| 作者姓名： | 冯巍 张明杰 |
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| 作者单位： | [1]中国科学院生物物理研究所,生物大分子国家重点实验室,北京100101 [2]香港科技大学生命科学部,分子神经生物学国家重点实验室,香港 |
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| 基金项目： | 香港研究资助局项目; 国家重点基础研究发展计划（“973”项目）（2011CB910503）; 国家自然科学基金项目（31070657）; 中国科学院重要方向性项目（KSCX2-YW-R-154 KSCX2-EW-J-3） |
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| 摘 要： | PDZ结构域是调控蛋白质/蛋白质相互作用的一类重要结构域,能特异结合蛋白质C末端一段有规律的氨基酸序列。含有PDZ结构域的支架蛋白能够组装成超大的蛋白质复合体来调控细胞内的信号转导通路。最新研究表明,PDZ结构域还能与PIP脂质直接相互作用,从而参与调控PIP脂质信号通路。将综合最新研究进展,阐明PDZ结构域与PIP脂质的作用方式,以及对相关PIP脂质信号转导的调控过程。
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| 关 键 词： | PDZ结构域 PIP脂质 信号转导 |
PDZ domain-mediated PIP lipid signaling |
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| FENG Wei,ZHANG Ming-Jie. PDZ domain-mediated PIP lipid signaling[J]. Chinese Bulletin of Life Sciences, 2011, 0(11): 1095-1100 |
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| Authors: | FENG Wei ZHANG Ming-Jie |
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| Affiliation: | 1 National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;2 Division of Life Sciences,State Key Laboratory of Molecular Neuroscience,Hong Kong University of Science and Technology,Hong Kong,China) |
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| Abstract: | PDZ domains are prevalent protein/protein interaction modules for specifically recognizing the extreme C-terminal tails of the proteins.The PDZ domain-containing scaffold proteins are capable of organizing supra-molecular signaling complexes to mediate signal transductions in cells.Recently,PDZ domains have been discovered to bind to PIP lipids directly,thus regulating the PIP lipid-mediated signaling pathways.In this review,on the basis of recent studies of the PDZ/lipid interactions,we describe the molecular basis of the PDZ/PIP lipid interactions and the PDZ domain-mediated regulation of the PIP lipid signaling. |
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| Keywords: | PDZ domain PIP lipids signal transduction |
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