Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo |
| |
Authors: | Shokoofe Noori Zuhair M Hassan Zohre Habibi Saeed Bayanolhagh |
| |
Institution: | a Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran b Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran c Department of Chemistry, Shahid Beheshti University, Tehran, Iran d Mycology Research Centre, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran |
| |
Abstract: | A regulatory or suppressor T cell is functionally defined as a T cell that inhibits an immune response by influencing the activity of another cell type. On the other hand, Th1 cells express IFN-γ and mediate cellular immunity.Sclareol exhibits growth inhibition and cytotoxic activity against a variety of human cancer cell lines. In the first set of experiments, Sclareol was isolated from the plant Salvia sclarea and our study assessed the immuno-therapeutic effectiveness of Sclareol by direct intra-tumoral injection. Secondly, several immunological parameters such as splenocytes proliferation, intra-tumor CD4+CD25+Foxp3+ Treg cells, IFN-γ and IL-4 secretion and tumor size were assessed to evaluate the anti-tumoral immune response. By all means, the findings confirmed that the activity of Sclareol could reduce the tumor growth in vivo against breast cancer. |
| |
Keywords: | Sclareol T regulatory cell (Treg cell) IFN-γ IL-4 Immuno-modulator |
本文献已被 ScienceDirect 等数据库收录! |
|