Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3 |
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| Authors: | P McWilliam G J Farrar P Kenna D G Bradley M M Humphries E M Sharp D J McConnell M Lawler D Sheils C Ryan |
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| Affiliation: | Department of Genetics, Trinity College Dublin, Ireland. |
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| Abstract: | ![]()
Members of a large pedigree of Irish origin presenting with early onset Type I autosomal dominant retinitis pigmentosa (ADRP) have been typed for D3S47 (C17), a polymorphic marker from the long arm of chromosome 3. Significant, tight linkage of ADRP to D3S47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the ADRP gene (RP1) segregating in this pedigree to 3q. |
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