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Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production |
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| Authors: | Juliana Coronel Christoph Heinrich Sandra Klausing Thomas Noll Alvio Figueredo-Cardero Leda R Castilho |
| Institution: | 1. Federal University of Rio de Janeiro (UFRJ), COPPE, Cell Culture Engineering Laboratory, Rio de Janeiro, RJ, Brazil;2. Xell AG, Alte Verler Straße 1, Bielefeld, Germany;3. Bielefeld University, Institute of Cell Culture Technology, Universitätsstraße 25, Bielefeld, Germany;4. Fiocruz, Bio-Manguinhos, Rio de Janeiro, RJ, Brazil |
| Abstract: | |
| Keywords: | CHO perfusion cultivation mild hypothermia productivity recombinant factor VIII valeric acid |