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The effect of prostaglandin F2β on expiratory flow rates |
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| Authors: | M.D. Paul Hamosh M.D. Angelo M. Taveira Da Silva |
| Affiliation: | aFrom the Department of Physiology and Biophysics Georgetown University School of Medicine Washington, D.C. 20007, USA |
| Abstract: | Prostaglandin F2β (PGF2β), a stereoisomer of F2 was administered by ultrasonic nebulization to eight patients with bronchial asthma and four normal subjects in increasing doses up to a 200 μg maximum dose. Maximum expiratory flow (MEF) and forced vital capacity (FVC) were analyzed at 5, 15, 30, 60 and 120 minutes after administration of aerosol. All expiratory flow rates were reduced after 5 minutes. Some increase in terminal flow rates was observed after 60 minutes. We conclude that PGF2β is not an effective bronchodilator at this dose level. |
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