Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis |
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Authors: | Biddinger Sudha B Hernandez-Ono Antonio Rask-Madsen Christian Haas Joel T Alemán José O Suzuki Ryo Scapa Erez F Agarwal Chhavi Carey Martin C Stephanopoulos Gregory Cohen David E King George L Ginsberg Henry N Kahn C Ronald |
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Institution: | Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. |
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Abstract: | Insulin resistance plays a central role in the development of the metabolic syndrome, but how it relates to cardiovascular disease remains controversial. Liver insulin receptor knockout (LIRKO) mice have pure hepatic insulin resistance. On a standard chow diet, LIRKO mice have a proatherogenic lipoprotein profile with reduced high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) particles that are markedly enriched in cholesterol. This is due to increased secretion and decreased clearance of apolipoprotein B-containing lipoproteins, coupled with decreased triglyceride secretion secondary to increased expression of Pgc-1 beta (Ppargc-1b), which promotes VLDL secretion, but decreased expression of Srebp-1c (Srebf1), Srebp-2 (Srebf2), and their targets, the lipogenic enzymes and the LDL receptor. Within 12 weeks on an atherogenic diet, LIRKO mice show marked hypercholesterolemia, and 100% of LIRKO mice, but 0% of controls, develop severe atherosclerosis. Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome. |
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Keywords: | HUMDISEASE SIGNALING |
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