| 人MIF基因启动子多态性与结核病易感性的关系 |
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| 引用本文： | 蹇锐,程小星,钟敏,王易伟.人MIF基因启动子多态性与结核病易感性的关系[J].微生物学杂志,2006,26(5):1-3. |
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| 作者姓名： | 蹇锐 程小星 钟敏 王易伟 |
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| 作者单位： | 1. 第三军医大学,微生物学教研室,重庆,400038
2. 重庆市肺科医院,重庆市结核基因诊断中心实验室,重庆,430020 |
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| 摘 要： | 为了研究巨噬细胞移动抑制因子(MIF)与结核病易感性的关系,分析了肺结核病人和正常人MIF基因启动子多态性。DNA测序分析的结果显示,正常人MIF基因启动子-794区CATT序列重复次数存在明显的差异,5、6和7个拷贝的几率分别是22.2%、44.4%和33.3%。7个肺结核病人中6人有6个拷贝,1人有7个拷贝,出现的频率分别为85.6%和14.3%。对比分析提示,肺结核病人MIF基因启动子区CATT低拷贝数(低于或等于6个)出现的频率明显高于正常人(85.6%比66.6%),可能同结核病的致病相关。
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| 关 键 词： | 基因多态性 MIF 启动子 结核 |
| 文章编号： | 1005-7021(2006)05-0001-03 |
| 修稿时间： | 2006年7月20日 |
Polymorphism of Human MIF Gene Promoter and Susceptibility to Tuberculosis |
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| JIAN Rui,CHENG Xiao-xing,ZHONG Min,WANG Yi-wei.Polymorphism of Human MIF Gene Promoter and Susceptibility to Tuberculosis[J].Journal of Microbiology,2006,26(5):1-3. |
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| Authors: | JIAN Rui CHENG Xiao-xing ZHONG Min WANG Yi-wei |
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| Abstract: | In order to study the relationship between macrophage migration inhibitory factor(MIF) and susceptibility to tuberculosis,mif promoter polymorphism was investigated in normal people and tuberculosis patients.DNA sequencing analysis showed that the number of CATT repeat at-794 region of mif promoter was different among normal Chinese people and the appearance of 5,6 and 7 repeat 22.2%,44.4%,and 33.3% respectively.Of 7 lung tuberculosis patients,6 had repeat(85.6%) and 1 had 7 repeat(14.3%).The rate of low copy number of CATT repeat (less or equal to 6) was significantly higher in lung tuberculosis patients than in normal people(85.6% vs 66.6%),suggesting that MIF might play a reciprocity in the pathogenesis of tuberculosis. |
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| Keywords: | polymorphism promoter MIF tuberculosis |
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